The following article was written by Jay Kilpatrick and originally published in the Proceedings of IJET-16 in 2005. Interest in the content of the article was rekindled at the August JATPHARMA meeting, and the author has made some minor corrections and deleted one section before re-publication.

Please note that because it has not been updated, the article may contain some out-of-date information. Nevertheless, we believe JAT members will still find a great deal of valuable guidance in this article.

Biomedical Translation, Version 2, Sept 2012